Samira Jadavi

Reports
Research activity
In the first year of my PhD, We investigated the interplay between protein aggregates characteristic and membrane composition and organization as a key factor in the cytotoxicity of amyloid aggregates. we used a protocol developed for preparing defect-free Supported Lipid Bilayers (SLBs) with the coexistence of both fluid and gel lipid phases. In particular, we employed two different lipid mixtures, mimicking the composition of both the external and internal leaflet of the neuronal cell membranes . Among all the possible protein misfolding diseases, we focused on Parkinson's disease (PD). We found that the interaction with alpha-synuclein, the principal peptide involved in PD, induced significant damages in SLBs with different extents in the two investigated lipid mixtures. Currently, We are going to perform correlative AFM-STED recordings to study the molecular mechanism of misfolded protein diseases and the formation of amyloid aggregates. In particular, we want to investigate the in vitro aggregation of alpha-synnuclein amyloid peptides.
Pubblicazioni IRIS
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Fluorescence labeling methods influence the aggregation process of α-syn in vitro differently
Anno: 2023
Autore/i: Jadavi, S.; Dante, S.; Civiero, L.; Sandre, M.; Bubacco, L.; Tosatto, L.; Bianchini, P.; Canale, C.; Diaspro, A. -
Advanced microscopy techniques applied to in-vitro study of Alpha synuclein aggregation and toxicity mechanism
Anno: 2022
Autore/i: Jadavi, Samira -
α-Synuclein interacts differently with membranes mimicking the inner and outer leaflets of neuronal membranes
Anno: 2022
Autore/i: Jadavi, S.; Canepa, E.; Diaspro, A.; Canale, C.; Relini, A.; Dante, S. -
Quantitative analysis of hypericin interaction with SARS-CoV 2 and with a model membrane
Anno: 2022
Autore/i: Mariangeli, M; Uriati, E; Usai, C; Mussini, A; Jadavi, S; Dante, S; Canale, C; Moreno, A; Delcanale, P; Abbruzzetti, S; Diaspro, A; Viappiani, C; Bianchini, P -
AFM-STED correlative nanoscopy applied to the study of in-vitro mis-folded protein aggregation
Anno: 2022
Autore/i: Jadavi, S; Dante, S; Bianchini, P; Diaspro, A; Canale, C