3D protein structure

Threedimensional protein structure

The research activity of this research line is focused on the 3D structure determination and analysis of macromolecules and their complexes with other proteins, and/or substrates/inhibitors using X-ray diffraction (on crystal and solution specimens), computer modeling and molecular simulation techniques. The protein crystals are grown in the fully equipped wet-lab located at the Physics Dept. such as the diffraction data analysis and structure determination using specific software programs.

The X-rays diffraction experiments on protein crystals are carried out at European Synchrotron Facilities (ESRF, Grenoble, France), while the experiments on protein solutions (Small Angle X-ray Scattering, SAXS) at DESY synchrotron (Hamburg, Germany).

The main research line is focused on 3D structure determination at high resolution of hemeproteins found in plants, invertebrates and bacteria and on low resolution structure of early aggregation states of amyloidogenic proteins.