Seminari & Eventi

Protein misfolding and amyloidosis XIII (Day 1)

When: Thursday, May 23, 2019 - 13:00
Where: Dipartimento di Fisica

Abstract:

13:00 – 13:10 Welcome from the Head of the Physics Department

Chair: Massimo Stefani
13:10 – 13:40 Marcus Fändrich (Institute of Protein Biochemistry, Ulm University) Cryo-EM structures of fibrils from systemic amyloidosis.

13:40 – 14:00 Stefano Ricagno (Department of Biosciences, University of Milan) Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient.

14:00 – 14:20 Francesca Lavatelli (Fondazione IRCCS Policlinico San Matteo and Department of Molecular Medicine, University of Pavia) Proteotoxicity of amyloidogenic cardiotropic light chains.

14:20 – 14:40 Giulia Fani (Department of Experimental and Clinical Biomedical Sciences, University of Florence) Identification of membrane Ca2+ channels activated by protein misfolded oligomers.

14:40 – 15:00 Maria Elena Regonesi (Department of Biotechnology and Bioscience, University of Milano-Bicocca) Characterization of CASA complex: role of HspB8 in protein quality control in Spinocerebellar Ataxia type 3 model.

Chair: Patrizia Polverino de Laureto
15:30 – 15:50 Valeria Crippa (Department of Pharmacological and Biomolecular Sciences, University of Milan) The clearance of aggregated TDP-43 responsible for ALS/FTD diseases 

15:50 – 16:10 Margherita Romeo (Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan) Investigating the spreading and toxicity of tau using C. elegans.

16:10 – 16:30 Chiara Maria Giulia De Luca (Fondazione IRCCS Istituto Neurologico Carlo Besta, Unit of Neurology 5 and Neuropathology, Milan) Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and Multiple System Atrophy.

Chair: Fabrizio Chiti
16:30 – 18:00 General discussion


Protein misfolding and amyloidosis XIII (Day 2)

When: Friday, May 24, 2019 - 09:00
Where: Dipartimento di Fisica

Abstract:

Chair: Luisa Diomede
9:00 – 9:20 Patrizia Polverino de Laureto (Department of Pharmaceutical and Pharmacological Sciences, CRIBI Biotechnology Centre, University of Padova) Could polyphenol compounds be promising drugs for Parkinson’s Disease? 

9:20 – 9:40 Manuela Leri (Department of Experimental and Clinical Biomedical Sciences, University of Florence) EVOO polyphenols can relieve autophagy dysregulation in Alzheimer's disease.

9:40 – 10:00 Giulia Faravelli (Department of Molecular Medicine, University of Pavia) C. elegans expressing D76N beta-2microglobulin: a useful model for screening drug candidates targeting amyloidosis. 

10:00 – 10:20 Stefano Thellung (Section of Pharmacology, Department of Internal Medicine and Centre of Excellence for Biomedical Research, University of Genoa) Prion protein fragment 90-231 impairs autophagic flux in neuronal cultures inducing cell death. 

10:20 – 10:40 Andrea Danani (IDSIA- Dalle Molle Institute for Artificial Intelligence, Manno, Switzerland) Structural polymorphism of Alzheimer’s beta amyloid fibrils.

Chair: Martino Bolognesi
11:00 – 11:20 Ciro Cecconi (Department of Physics, Informatics and Mathematics, University of Modena and Reggio Emilia, and Institute of Nanoscience S3, CNR) Single-molecule studies of the molecular mechanisms underlying the chaperone activity of HSPB8.

11:20 – 11:40 Claudio Canale (Department of Physics, University of Genoa) Unexpected asymmetry in the aggregation of partially labeled peptides. 

11:40 – 12:00 Alberto Diaspro (Department of Physics, University of Genoa and Nanoscopy, IIT) Multi-Messenger Optical Microscopy to study biological macromolecules in cells. 

12:00 – 12:10 Luca Oberti (Department of Biosciences, University of Milan) Rationally designed mutant light chain highlights properties modulating the soluble toxicity 

12:10 – 12:15 Davide Odino (Department of Physics, University of Genoa) Trodusquemine induces changes in the properties of biomimetic membranes. 

12:15 – 12:20 Mattia Siri (Department of Pharmaceutical Sciences, University of Genoa) Inhibition of amyloid beta aggregation by multi-target compounds. 

12:20 Final discussion


Laurea Magistrale

When: Wednesday, June 5, 2019 - 15:00

Holographic Charge Density Waves

Speaker:
Dr. Marcello Scanavino
When: Thursday, June 6, 2019 - 14:30
Where: Dipartimento di Fisica - Aula 500

Abstract:

Fisica Teorica

In many condensed matter systems, the strongly coupled electronic fluid tends to spontaneously break translational symmetry, giving rise to a Charge Density Wave (CDW). Gauge/Gravity duality can be used to study some properties otherwise not accessible by field theory approaches. We will see how to study the transport properies of a CDW by using a class of holographic models.

 


The Cherenkov Telescope Array: probing the extreme edge of the electromagnetic spectrum

Speaker:
Dott. Fabrizio Tavecchio
INAF-Osservatorio di Brera
When: Wednesday, June 12, 2019 - 14:30
Where: Dipartimento di Fisica - Aula 500

Abstract:

Seminario generale

In the next years we expect a dramatic leap in our knowledge of high-energy astrophysical phenomena, triggered by the first observatory for very-high-energy gamma-ray astronomy, the Cherenkov Telescope Array (CTA). Thanks to the unprecedented sensitivity (more than one order of magnitude better than current instruments), the improved angular resolution and the wide energy coverage (from 20 GeV up to 300 TeV), CTA carries an enormous scientific potential for discovery. After an introduction on the detection technique and the expected performances, I will review some of the more interesting physical topics in the focus of CTA. In particular I will discuss the possibility to discover the most extreme galactic accelerators (so-called Pevatron), to study extreme phenomena acting in relativistic jets and to characterize the extragalactic background light and the intergalactic magnetic field.


Laurea

When: Thursday, July 4, 2019 - 15:00

Laurea Magistrale

When: Wednesday, July 17, 2019 - 15:00

Laurea

When: Thursday, July 25, 2019 - 15:00

Laurea Magistrale

When: Wednesday, September 25, 2019 - 15:00

Laurea

When: Thursday, September 26, 2019 - 15:00

Laurea

When: Thursday, October 24, 2019 - 15:00

Laurea Magistrale

When: Wednesday, October 30, 2019 - 15:00

Laurea Magistrale

When: Wednesday, November 27, 2019 - 15:00

Laurea

When: Thursday, January 16, 2020 - 15:00

Laurea Magistrale

When: Wednesday, February 12, 2020 - 15:00

Laurea

When: Thursday, February 20, 2020 - 15:00

Laurea Magistrale

When: Wednesday, March 25, 2020 - 15:00

Laurea

When: Thursday, March 26, 2020 - 15:00

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